Zach Galifianakis: Think Bill Murray doing Garfield. All great comedians deserve a nice paycheck every now and then, and letting Galifianakis do his free-association-riffing thing could be pretty darned funny. (Three words: Horse. Playing. Piano.)
Werner Herzog: The game-for-anything auteur is already signed on to play the villain in a new Tom Cruise movie. He has also voiced a plastic bag and a character on The Simpsons. And given his natural fascination with all things nature, surely he would find something amusingly profane about voicing a horse who knows more about human affairs than humanity.
Justin Bieber: Mr. Ed sings!
Lea Michele: Mr. Ed sings, and also now he’s Ms. Ed!
JB Smoove: This would be if they decide to take Mr. Ed: The Movie in a slightly more R-rated direction. Smoove has spent a few seasons on Curb Your Enthusiasm giving incredibly NSFW advice to Larry David. Just replace “Larry” with “Wilbur,” and you’ve got a typical episode of Mr. Ed.
Who would you like to hear as the voice of Mr. Ed when your kids drag you to see this movie in a couple years?